Americans are coffee addicts, and perhaps more so nowadays, now that we’re working longer hours and getting less sleep than decades past. 50% of Americans drink at least one cup per day. In the past, the pendulum on coffee, and in particular caffeine, swung back and forth as to whether moderate consumption was healthy or not. At one time, too much was thought bad for the heart.

Today, moderate caffeine consumption is actually considered healthy. Tea and coffee both contain antioxidants which rid the body of free radicals—proven to harm cells. One recent study found that coffee consumption in women can decrease the risk of dementia . Another found that drinking coffee can lessen the impact of liver disease.

In a recent study published online in the journal Nature Medicine , researchers at Stanford University discovered that among certain adults, caffeine can block an inflammation pathway which leads to heart disease. 100 human participants underwent extensive assessment, including giving researchers their family and medical histories, answering survey questions, and giving blood. This pathway is associated with low-grade, chronic inflammation, known to contribute to disease and aging.

Nucleic acid metabolites are byproducts of processes that circulate in the blood and trigger inflammation. Chronic, low-grade inflammation has been linked to heart disease, Alzheimer’s, dementia, osteoarthritis, certain types of cancer, and even depression. According to the study’s lead author David Furman, PhD, “More than 90 percent of all non-communicable diseases of aging are associated with chronic inflammation.”

Recent studies show that moderate caffeine consumption offers tremendous health benefits.

Mark Davis, PhD was a senior author on this study. He’s the director of the Stanford Institute for Immunity, Transplantation, and Infection. Besides helping to prevent disease, “It’s also well-known that caffeine intake is associated with longevity,” Davis said. “Our findings show that an underlying inflammatory process, which is associated with aging, is not only driving cardiovascular disease but is, in turn, driven by molecular events that we may be able to target and combat.” Target in medical speak often means potentially treatable with drug therapy, which could reap exciting benefits for certain patients.

Still, their findings aren’t airtight. The inflammatory mechanism researchers discovered was present in some, but not all participants. Interestingly, those who were found to have a less active pathway or mechanism tended to consume higher levels of caffeine. Turning to the lab, these scientists soon saw that among older patients who tended to drink more coffee or tea, the inflammatory mechanism was inhibited.

At the opening of the study, researchers perused data from a long-term project a decade old, the Stanford-Ellison cohort. This is a longitudinal study on the immunology of aging. Here, the immune systems of 20 to 30 year-olds is compared to those of adults over age 60. Participants give blood annually and answer survey questions and all the data is recorded.

In the caffeine study, researchers compared blood samples from younger participants to older ones, to see what genes were active in old age. Two groups of genes were of interest. Each help produce an inflammatory protein that circulates throughout the body, known as IL-1-beta.

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